Description du poste
L’Institut des Maladies Infectieuses de l’Université de Berne offre des postes de recherche.TâchesExplorer les interactions entre pathogènes intestinaux et microbiote.Évaluer les contributions microbiologiques via des modèles gnotobiotiques.Modéliser mathématiquement les paramètres de résistance à la colonisation.CompétencesFormation solide en biologie/microbiologie requise.Compétences en techniques de laboratoire et biologie cellulaire.Capacité à travailler en équipe multidisciplinaire.The Institute for Infectious Diseases performs tasks in teaching and research as well as in diagnostic microbiology in the fields of virology, bacteriology, mycology, parasitology and serological infection clarification. It is the only university institute in Switzerland that combines all microbiological specialties in the field of clinical microbiology under one roof.We invite applications for up to two PhD or postdoctoral research positions in our group, focusing on intestinal pathogen-microbiome-host interactions. Our research aims to uncover key microbial metabolic and immunological pathways that contribute to intestinal colonization resistance against Clostridioides difficile, with the long-term goal of developing innovative microbiome-based therapies.About the projectThe successful candidates will employ cutting-edge approaches to investigate:The mechanisms by which microbiome composition influences C. difficile infection resistance.Microbiome xenotransplantation in germ-free mice to assess functional microbial contributions.Metagenome-informed design of synthetic bacterial communities and their study in gnotobiotic models.Genetic modification of C. difficile for isogenic genomic barcoding to track population dynamics, within-host evolution, and persistence mechanisms.Mathematical modeling of colonization resistance parameters using these data.Our research moves beyond correlative microbiome analyses toward a better mechanistic understanding of microbiome function, leveraging internationally leading germ-free, gnotobiotic, and reversible gnotobiotic mouse models, combined with advanced microbial genetics and metagenomics.What we offerThe positions are embedded within the frameworks of the NCCR Microbiomes (www.nccr-microbiomes.ch), a Swiss research network at the forefront of microbiome science, and the Multidisciplinary Center for Infectious Diseases (MCID; https://www.mcid.unibe.ch) at the Univeristy of Bern, fostering interdisciplinary collaborations between microbiologists, immunologists, functional metagenomics experts, and mathematical modelers. Through these networks, candidates will gain access to state-of-the-art facilities, diverse training programs, and unique opportunities to collaborate with international leaders in the field.The Institute for Infectious Diseases (IFIK) of the University of Bern offers research, teaching, and diagnostic services in all specialties of medical microbiology. It is the only Swiss university institute that integrates comprehensive expertise in virology, bacteriology, mycology, parasitology, and infection serology under one roof.To learn more about our research and methodologies, check out our key publications:1. https://doi.org/10.1126/science.11884542. https://doi.org/10.1038/s41467-020-15891-93. https://doi.org/10.1038/s41586-020-2564-64. https://doi.org/10.1080/19490976.2023.2172667Who Should Apply?Strong academic performance and a solid foundation in biology/microbiology.Scientific curiosity, integrity, and excellent analytical skills.Proficiency in basic wet-lab techniques, including molecular biology and bacterial or mammalian cell biology.Experience in any of the following is a plus: animal models (especially infection models or gnotobiology), microbiome analysis, microbial genetics, or mucosal immunology, microbial ecology, or mathematical modeling.Ability to work independently and collaboratively in a multidisciplinary environment.Terms of EmploymentFixed-term contracts initially for one year, renewable for at least three additional years.Full-time (100%) positions are available, but reduced-pensum arrangements (e.g., 60-80%) can be considered to support candidates with family or other obligations.Start Date and Application DeadlinePositions are available from July 2025 or upon mutual agreement. Application deadline: 18. June 2025.How to applyTo apply, please send a (i) CV (including names of former mentors and supervisors), (ii) a brief statement of research interests, (iii) grades from undergraduate/graduate studies, (iv) a publication list (if applicable), and (v) contact information or letters of at least two references comnined into a single PDF document by e-mail toE-Mail schreiben. Lire la suite
